Yes, the MobileStudio can be used in Hybrid mode with a computer running Windows or OSX. For this you need the additional Wacom Link / Wacom Link Plus adapter or a USB-C to USB-C supporting DisplayPort Alternate Mode and USB 3.1.
Wacom Link - ACK42719: for DTH-W1320, DTH-W1620 models
Wacom Link Plus - ACK42819: for DTH-W1621 models
Manual: http://101.wacom.com/UserHelp/en/Setup1_MSP.htm