Yes, the current driver supports macOS 11 Big Sur.

This OS has added many security features to keep the computer safe from applications not downloaded directly from the App Store. If an app is downloaded from the internet or directly from a developer (e.g., the Wacom Driver), the OS continues to protect the Mac. These added protections require adjustments to security settings. The settings will need to be adjusted to allow the app access to certain parts of the OS. Until these settings are accepted, the tablet functions, such as the Pen and touch input, may not work correctly.

Below are the steps to install the driver for a tablet on macOS 11.0.x and adjust the required security settings. 

Step 1: Compatibility

To be compatible with macOS 11.0 Big Sur, the device must be supported by the 6.3.40-* driver or newer. To check which devices are compatible, visit the Wacom Driver Page, open the driver release notes, and select the "compatible products" link.

When installing the driver, the message "The Wacom Tablet Driver can't be opened because it is from an unidentified developer" may appear. This means the computer's security settings allow downloads only from the Apple App Store. To install the Wacom Driver, the computer's security settings will also need to be adjusted. For more information on security and steps to allow installs from unidentified developers, visit Apple's support page here.

Step 2: Installing the Driver

• Download the current driver and run the installer.
• During the install, you will be prompted to add the required security settings. Make sure to add these settings; otherwise, the tablet and driver will not work correctly.
• Next, you must restart your computer for the driver to start working.
• Once the driver has been installed, connect your device to the computer

Note: When prompted for permissions during installation, choose to allow.

Note: Permissions must be added within the first 30 minutes after installing the driver. If the driver was installed outside the time window, please uninstall and reinstall it.

A tutorial walkthrough of the Driver installation process is also available here.

Install Process Prior to Driver 6.3.42.

Step 2: Installing the Driver

• Download the current driver and run the installer.
• During the install, you will be prompted to add the required security settings. Make sure to add these settings; otherwise, the tablet and driver will not work correctly.
• Next, you must restart your computer for the driver to start working.
• Once the driver has been installed, connect your device to the computer

Step 3: Security & Privacy Permissions

Follow these steps if you were not prompted for permissions, or if your pen or touch is not working correctly. If the pen or touch is not working after installation, check these settings even if you were prompted to allow the permissions.

• Go to the Apple menu, open System Preferences, and select Security & Privacy.
• Go to the Privacy tab, select Accessibility, then click on the lock at the bottom of the preferences to make changes. You will be asked to input your credentials.
• On the list shown, make sure any Wacom component listed has a checkmark.
  • While you are here, ensure any known applications listed have a check as well. (For example, Photoshop will need to be selected to work correctly with the tablet. Visit the Adobe support guide for more information on adding this program if it's missing.
  • If any Wacom component is listed here, and the pen or touch is still not working, "select" the Wacom items listed, and then click the "-" sign below the list to remove them. Next, restart the computer and go to Step 4. 

• Scroll down to "Input Monitoring" and add a check mark for WacomTabletDriver and Firmware Updater

• Scroll down to Files and Folders, locate Wacom Desktop Center, and turn on any checkmarks attached to Wacom Desktop Center.
• Note: When you add an item in Input Monitoring, a message will appear notifying you that the application must quit before the changes will work. Please do so; however, you must restart your computer afterward, as the tablet and driver will not work properly until then.

Step 4: If the issue continues or if no Wacom components are listed

If no Wacom components are listed, move the Security & Privacy preferences aside; we will need to return here in a few steps.

• Click on the desktop and press Command+Shift+G, open Finder, or click Go on the Menu Bar and select Go to Folder
• Type: /Library/ PrivilegedHelperTools/ then press GO
• Locate the com.wacom.IOManager.app
• Please make sure you are still allowed to make changes (the lock is open), then drag and drop com.wacom.IOManger.app to the list under Accessibility in the Security & Privacy section. Ensure the new item is checked.
  • If this item does not check, there may be an issue with your Mac OS, and you need to contact Apple Support.
• Close the preferences, restart your computer.
• Next, scroll down to Files and Folders, locate Wacom Desktop Center, and turn on any checkmarks associated with it.
• Next, under Automation, also in the privacy tab in the Security & Privacy. Any Wacom components here should also have checkmarks. If the Wacom Desktop Center isn't listed, it hasn’t requested control from the OS yet. To add the Wacom Desktop Center to Automation, follow the steps below.
  • Launch the Wacom Desktop Center
  • Select your device and go to any of the settings (such as pen settings)
  • A dialog will open; make sure to allow the app.
  • Close the preferences, restart your computer.
  • Go to the Privacy tab again, select Accessibility, then click on the lock at the bottom of the preferences to make changes.
  • Uncheck the com.Wacom.IOManager, then log the user out.
  • Login into the user again, open Accessibility, and check the add the driver setting again