Not currently, however Wacom does plan to fully support macOS 12 as soon as possible.
Apple has announced the upcoming macOS 12, Monterey. This operating system is still in development and has not been released yet. Wacom currently does not offer a driver for this OS. As a note, Beta and prerelease versions of an OS may be released to the public before the official launch of the OS by Apple. These pre-release versions are not supported by Wacom. For continued use and driver support of your Wacom Product, please delay the installation of the new OS until after Wacom announces support for the OS.