The Wacom Professional Service is stopped or is not running may be caused by a failed startup, the Wacom service was manually stopped, or if the Wacom service or set it to manual.
To resolve the issue, please restart your computer. If you receive the same error message, please uninstall and reinstall the driver with the current version. If the issue continues, please contact Wacom support.
Steps to uninstall and reinstall the driver can be found here